Table 2. Univariate and Multivariable Analysis of Variables Independently Associated with Disease-Free Survival.

Characteristics	No. of Patients	Univariable Analysis		Multivariable Analysis
		Hazard Ratio	P	Hazard Ratio	P
Age (years)		1.071 (0.925–1.240)	0.361
Detection modality
Mammography (ref.)	197
US	43	0.086 (0.001–0.613)	0.007	0.097 (0.001–0.705)	0.014
Breast disease with high risk for breast cancer
Absent (ref.)	224
Present	16	0.259 (0.002–1.852)	0.231
Family history of breast cancer
Absent (ref.)	226
Present	12	0.832 (0.112–6.173)	0.857
Surgery type
Breast-conserving surgery (ref.)	105
Total mastectomy	135	0.887 (0.396–1.984)	0.770
Invasiveness
Non-invasive (ref.)	51
Invasive	189	1.916 (0.571–6.423)	0.292
Tumor size (cm)	240	1.577 (1.107–2.246)	0.012	0.975 (0.637–1.443)	0.902
T stage
T0 (ref.)	51
T1	141	1.468 (0.414–5.201)	0.552
T2	48	3.234 (0.875–11.950)	0.078
T3	0
T4	0
N stage
Nx
N0 (ref.)	183
N1	36	1.285 (0.426–3.872)	0.656
N2	14	2.947 (0.853–10.187)	0.088
N3	7	3.958 (0.902–17.365)	0.068
Histology grade
Not-high (ref.)	173
High	67	2.789 (1.252–6.210)	< 0.012	2.457 (1.108–5.451)	0.027
Chemotherapy
Absent (ref.)	113
Present	127	2.102 (0.870–5.077)	0.099
Endocrine therapy
Absent (ref.)	66
Present	173	0.913 (0.377–2.213)	0.840
Radiation therapy
Absent (ref.)	114
Present	126	1.870 (0.799–4.377)	0.149
Estrogen receptor
Negative (ref.)	66
Positive	168	0.973 (0.402–2.353)	0.951
Progesterone receptor
Negative (ref.)	69
Positive	165	0.858 (0.366–2.011)	0.724
HER2 receptor
Negative (ref.)	154
Positive	47	1.025 (0.375–2.799)	0.961
Unknown	33	0.796 (0.232–2.732)	0.717

HER2 = human epidermal growth factor receptor 2, ref. = reference