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. 2021 Jan 7;10:534095. doi: 10.3389/fonc.2020.534095

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Copyright © 2021 Chen, Wang, Huang, Xu, Lv, Nie, Wang, Zhao, Liu, Li, Lu, Zhang and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kremen2 knockdown inhibited survival of GC cells through the PI3K/Akt pathway. SGC-7901 cells were stably transfected with Lenti-shKremen2 or Lenti-shCtrl and cell lysate was analyzed using antibody array and western blot. (A) The spots of apoptosis antibody array after knockdown of Kremen2. (B) The position of each protein in the antibody array. (C) Fold change of each protein in the antibody array. (D) Semi-quantitative analysis of change of caspase 3, caspase 8, CD40L, p21, p27, p53 and TNF-α following Kremen2 knockdown. (E) Kremen2 knockdown down-regulated expression of p-Akt, Akt, E2F1, PI3K and cyclin D. *P < 0.05; **P < 0.01.