Fig. 2. G/C vs. A/T bp content at positions 3, 8, 13, and 18 distinguishes REs linked to distinct p53-driven cell fates.

a The list of sixteen pro-apoptotic p53 REs (bottom) and 16 previously confirmed REs corresponding to genes driving p53-dependent pro-survival response (top)¹⁹, with their nucleotide sequence. Lower-case letters in RE sequences indicate mismatches from p53 RE consensus. The last column shows the number of G/C bps at positions 3, 8, 13, and 18, emphasizing a tendency of pro-apoptotic REs having ≥ 2, and pro-survival REs having ≤ 2. b Motif analysis of pro-survival (top) and pro-apoptotic (bottom) REs listed in a. Positional analysis confirms an increased frequency of G/C bps at the core sequence-adjacent positions among pro-apoptotic REs and A/T bps among pro-survival REs. Source data are provided as a Source Data file.