Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 7;7:622778. doi: 10.3389/fcvm.2020.622778

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Bianchini, Auditeau, Razanakolona, Vasse and Borgel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Simplified overview of the coagulation and fibrinolysis processes. Coagulation is initiated at site of injury by TF-FVIIa complex that activates FIX and FX. FXa catalyzes thrombin (FIIa) formation, that amplifies its own generation by activating FXI and cofactors FVIII and FV. Thrombin also promotes platelet aggregation and fibrinogen into fibrin conversion to form a stable thrombus. Fibrinolysis is triggered once the clot is formed by tPA-induced plasminogen (plg) activation. The resulting plasmin (pln) enzyme is then responsible of fibrin degradation. The targets of the principal anticoagulant and antifibrinolytic serpins, as well as that of anticoagulant aPC are indicated with color capped arrows.