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Mechanism of action of riAT as reversal agent for heparin derivatives anticoagulant activity. (A) In situation of bleeding risk associated with the use of heparin derivatives (yellow), (B) administration of riAT (light pink) could displace heparin derivatives from endogenous AT (red) to riAT by a competition mechanism. (C) Hence, heparins are found trapped in an inactive complex with riAT, reducing thereby their apparent anticoagulant activity.
