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. 2021 Jan 7;14:592664. doi: 10.3389/fnins.2020.592664

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Copyright © 2021 Parsons and Huizinga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of carbenoxolone on clusters and gaps in the presence of SNP. (A) Cluster, gap and cycle (cluster-gap or gap-cluster) durations without SNP (control), with 1 μM SNP and after incrementing carbenoxolone to various concentrations as indicated. (B) Absolute percentage change in duration from cluster to cluster or gap to gap. (C) Absolute percentage change in duration from cycle to cycle. All values are means (standard error for data from six intestines. n’s (number of clusters, gaps or cycles) range from 46 to 104 and are not shown for clarity. p values are by Mann Whitney rank sum z-test between SNP and carbenoxolone. In panel (A) p values are not shown for gap-cluster cycles for clarity. p values for control against SNP are also not shown for any of the graphs. The same p scale shown to the right of panel (B) applies to all graphs.