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. 2021 Jan 7;8:619199. doi: 10.3389/fcell.2020.619199

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Copyright © 2021 Odegaard, Schaal, Clark, Koul, Sankarasubramanian, Xia, Mellon, Uberti, Liu, Stothert, Van Hook, Wang, Guda, Lisco, Pendyala and Yelamanchili.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolite concentrations in the hippocampus measured by ¹H-MRS at P17 in PNO and IUO animals. Measured metabolites included Alanine (ALA), Aspartate (ASP), Creatine (CRE), Gamma-Aminobutyric acid (GABA), Glucose (GLC), Glutamine (GLN), Glutamate (GLU), Glycine (GLY), Lactate (LAC), Myo-inositol (MYO), N-Acetyl Aspartate (NAA), Phosphorylcholine (PC), Taurine (TAU), and total choline (tCHO). In all groups, n = 6 for all metabolites except Lac (n = 4 in the IUO group). All data represented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001.