Table 2.

Univariable and multivariable Cox regression analysis for the risk of CKD I–IIIa progression to CKD IIIb among the Early CKD Care Programme and other risk factors (n=3114)

	Univariable		Multivariable*
	HR (95% CI)	P value	aHR (95% CI)	P value
Group
Control	ref		ref
Case	0.72 (0.61 to 0.85)	<0.0001	0.67 (0.55 to 0.81)	<0.0001
Comorbidity number
0	ref		ref
1	0.99 (0.77 to 1.29)	0.9687	0.80 (0.54 to 1.17)	0.2438
2	0.94 (0.73 to 1.21)	0.6374	0.54 (0.29 to 1.02)	0.0592
3+	1.16 (0.93 to 1.46)	0.1931	0.46 (0.17 to 1.23)	0.1195
Hypertension
No	ref		ref
Yes	0.98 (0.82 to 1.16)	0.7803	1.24 (0.85 to 1.81)	0.2654
DM
No	ref		ref
Yes	1.30 (1.07 to 1.58)	0.0075	1.72 (1.23 to 2.41)	0.0015
Gout
No	ref		ref
Yes	0.86 (0.67 to 1.11)	0.2577	1.25 (0.87 to 1.77)	0.2241
Hyperlipidaemia
No	ref		ref
Yes	0.98 (0.81 to 1.19)	0.8467	1.26 (0.88 to 1.80)	0.2152
Heart disease
No	ref		ref
Yes	1.29 (1.06 to 1.58)	0.0132	1.70 (1.20 to 2.40)	0.0027
Cerebrovascular disease
No	ref		ref
Yes	1.36 (1.04 to 1.78)	0.027	1.59 (1.12 to 2.27)	0.0104

*The multivariable model was adjusted for all variables.

aHR, adjusted HR; CKD, chronic kidney disease; DM, diabetes mellitus; ref, reference.