Table 3.

Univariable and multivariable Cox regression analysis for the risk of baseline stage <3 a progression to stage 3b and stage 3a progression to stage 3b among the Early Chronic Kidney Disease Care Programme and other risk factors

	Baseline stage <3a n=1382				Baseline stage=3a n=1732
	Univariable		Multivariable*		Univariable		Multivariable*
	HR (95% CI)	P value	aHR (95% CI)	P value	HR (95% CI)	P value	aHR (95% CI)	P value
Group
Control	ref		ref		ref		ref
Case	0.75 (0.52 to 1.08)	0.1244	0.75 (0.48 to 1.17)	0.2059	0.72 (0.60 to 0.87)	0.0005	0.34 (0.51 to 0.80)	<0.0001
Comorbidity number
0	ref		ref		ref		ref
1	0.61 (0.33 to 1.12)	0.109	0.50 (0.20 to 1.26)	0.142	1.09 (0.82 to 1.46)	0.5593	0.87 (0.56 to 1.35)	0.5345
2	0.82 (0.49 to 1.38)	0.4528	0.59 (0.14 to 2.48)	0.4753	0.95 (0.71 to 1.27)	0.7322	0.51 (0.25 to 1.05)	0.0664
3+	0.99 (0.57 to 1.72)	0.9617	0.64 (0.06 to 6.54)	0.7025	1.18 (0.91 to 1.52)	0.2062	0.39 (0.13 to 1.20)	0.1013
Hypertension
No	ref		ref		ref		ref
Yes	0.93 (0.63 to 1.36)	0.6964	1.10 (0.45 to 2.66)	0.7025	0.99 (0.81 to 1.20)	0.8805	1.32 (0.86 to 2.03)	0.2019
DM
No	ref		ref		ref		ref
Yes	1.48 (0.94 to 2.34)	0.0932	1.99 (0.87 to 4.54)	0.1032	1.26 (1.01 to 1.57)	0.0385	1.69 (1.16 to 2.47)	0.0065
Gout
No	ref		ref		ref		ref
Yes	0.79 (0.43 to 1.46)	0.4536	1.05 (0.45 to 2.43)	0.9181	0.89 (0.67 to 1.19)	0.4329	1.34 (0.90 to 1.99)	0.1525
Hyperlipidaemia
No	ref		ref		ref		ref
Yes	0.73 (0.48 to 1.11)	0.1404	0.76 (0.34 to 1.70)	0.5014	1.07 (0.87 to 1.33)	0.5204	1.52 (0.99 to 2.30)	0.0507
Heart disease
No	ref		ref		ref		ref
Yes	1.20 (0.74 to 1.93)	0.4599	1.47 (0.70 to 3.12)	0.3093	1.24 (0.99 to 1.56)	0.0618	1.65 (1.12 to 2.45)	0.0124
Cerebrovascular disease
No	ref		ref		ref		ref
Yes	1.78 (0.97 to 3.28)	0.0644	1.89 (0.84 to 4.26)	0.1247	1.25 (0.92 to 1.70)	0.1602	1.48 (0.99 to 2.21)	0.0576

*The multivariable model was adjusted for all variables.

aHR, adjusted HR; DM, diabetes mellitus.