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. 2021 Jan 19;9(1):e001460. doi: 10.1136/jitc-2020-001460

Figure 2.

Figure 2

Direct and indirect signaling pathways downstream of PD-1 blockade in myeloid cells. PD-1 blockade results in direct (left) and indirect (right) signaling outcomes. Direct PD-1 blockade in PD-1 expressing myeloid cells activates NF-κB and pSTAT1 signaling pathways and reprograms glycometabolism (left). In the indirect pathway, anti-PD-1 activated T cells secrete IFN-y which triggers NF-κB and pSTAT1 signaling pathways in myeloid cells (right). Arrows indicate downstream outcomes of PD-1 blockade. IFN-γ, interferon gamma; PD-1, programmed cell death protein 1.