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. 2021 Jan 18;9(1):e001334. doi: 10.1136/jitc-2020-001334

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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NK cell-resistant tumor cells induce clustering but not polarization of NK cell lytic granules. (A) Time-lapse imaging of NK-92 cocultured with the resistant MDA-MB-453 cell line. White arrows indicate conjugations of NK-92 with target cells. Representative images are shown. Time in hh:mm. (B, C) Granule clustering (B) and granule polarization (C) were quantified preconjugation and postconjugation in the same manner as in figure 2. Combined data from at least three independent experiments. (D) Histograms show LFA-1 expression in NK-92 cells and ICAM-1 expression in MDA-MB-453 cells, analyzed by flow cytometry. Corresponding isotype controls are depicted in gray. Representative data from at least 3 independent experiments are shown. IS, immunological synapse; NK, natural killer; ns, not significant. **P<0.01.