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. 2021 Jan 21;6:27. doi: 10.1038/s41392-020-00388-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Treatment with the γ-secretase inhibitor DBZ reduced the ALDH-bright population in MEC cells. a Human MEC cells (H3118, UM-HMC-3B, and H292) were treated with various concentrations of DBZ for 72 h. The DBZ-treated cells were harvested for western blotting to analyze the levels of activated form of NOTCH1 (cleaved NOTCH1), the total NOTCH1, and HES1 proteins. b The number of the DBZ-treated cells were scored. c The DBZ-treated cells were assayed for the percentage of ALDH^br cells using an ALDEFLUOR™ Kit (ns, p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001)