Figure 1.

Characterization of the vasculature of intracranial tumor models

The leakiness of the vasculature of intracranial GBM8, U87, Mel57, and Mel57VEGF tumors was assessed by T2-weighted, T1-weighted pre-contrast and T1-weighted post-gadolinium (Gd) contrast magnetic resonance imaging, by autoradiography following intravenous (i.v.) administration of ¹⁴C-aminoisobutyrate (AIB) and by fluorescence microscopy following i.v. Texas Red (TxRed). Histochemical hematoxylin and eosin (H&E) staining was used as a reference for tumor location. P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) expression was demonstrated by immunohistochemistry. All of the microscopy images are representative of n = 5–13 animals. Scale bars, 100 μm.

See also Figures S1 and S2.