Figure 2.

Docetaxel distribution in brain tumors

The docetaxel concentration was lower in Mel57, U87, and GBM8 tumors of wild-type (WT) mice compared to Abcb1a/b^−/− mice, but considerably higher than in surrounding normal tissues (right hemisphere, left hemisphere, and cerebellum) in all tumors but GBM8. Tissues were harvested at 4 h after 30 mg/kg i.v. docetaxel. Data are represented as means ± SEs (n = 9–12); ∗∗∗∗p < 0.0001, for tumor compared to WT; ⁺p < 0.05, ⁺⁺⁺⁺p < 0.0001 for normal brain compared to tumor in the same genotype. ⁺⁺p < 0.01.