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. 2021 Jan 19;2(1):100184. doi: 10.1016/j.xcrm.2020.100184

Figure 4.

Figure 4

BBB permeability affects the efficacy of treatment against intracranial GBM tumors

(A) Efficacy of docetaxel against intracranial GBM8 tumors grafted in WT or Abcb1a/b;Abcg2−/− mice. Data are represented as means ± SEs (n ≥ 6).

(B) Efficacy of docetaxel against intracranial U87 tumors grafted in WT or Abcb1a/b−/− mice. Data are represented as means ± SEs (n ≥ 6); ∗∗∗∗p < 0.0001.

(C) Efficacy of paclitaxel against intracranial U87 tumors grafted in WT or Abcb1a/b−/− mice. Data are represented as means ± SEs (n ≥ 7); ∗∗∗∗p < 0.0001.

In all of the panels, arrows indicate the days of taxane administration.

See also Figure S3.