Table 2.
Functional data of HFD mice with or without A779 treatment.
| Groups | CTL (n = 6) |
HFD (n = 6) |
HFD + A779 (n = 6) |
|---|---|---|---|
| Body weight (g) | 24.6 ± 1.3 | 33.1 ± 2.5* | 28.8 ± 1.2*# |
| KW/TL (g/cm) | 0.13 ± 0.01 | 0.17 ± 0.01* | 0.17 ± 0.01* |
| S-Glu (mmol/dL) | 4.55 ± 0.52 | 12.37 ± 0.82* | 8.64 ± 0.01*# |
| S-FFA (mmol/L) | 593 ± 35 | 992 ± 75* | 695 ± 83*# |
| S-Chol (mg/dL) | 2.67 ± 0.06 | 3.47 ± 0.23* | 3.15 ± 0.24* |
| S-TG (mg/dL) | 0.51 ± 0.06 | 0.53 ± 0.04 | 0.59 ± 0.15 |
| S-HDL (mmol/L) | 2.06 ± 0.02 | 2.16 ± 0.05* | 2.31 ± 0.02*# |
| S-LDL (mmol/L) | 0.56 ± 0.02 | 0.61 ± 0.02* | 0.82 ± 0.05*# |
| S-Cr (μmol/L) | 12.2 ± 0.91 | 12.8 ± 0.49 | 14.3 ± 0.59 |
| CCr (μl/min/g) | 11.65 ± 1.44 | 5.60 ± 0.67* | 7.37 ± 0.49* |
| U-Alb (μg/24 h) | 4.22 ± 1.05 | 13.17 ± 3.25* | 6.78 ± 1.89# |
| UACR | 0.12 ± 0.02 | 0.21 ± 0.01* | 0.17 ± 0.01*# |
HFD high-fat diet, KW kidney weight, TL tibia length, S-Glu serum glucose, S-FFA serum-free fatty acid, S-Chol serum cholesterol, S-TG serum triglycerides, S-HDL serum high-density lipoprotein, S-LDL serum low-density lipoprotein, S-Cr serum creatinine, Ccr clearance of creatinine, U-Alb urine albumin, UACR urine albumin to creatinine ratio.
*P < 0.05 when compared with CTL group, #P < 0.05 when compared with HFD group.