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. 2021 Jan 7;11:616145. doi: 10.3389/fphys.2020.616145

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Copyright © 2021 Shao, Dong, Cai, Tang, Xie, Yan, Luo and Jing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of local oxygen enrichment on the gene expression and protein production of cytokines in lung tissues of rats exposed to 4-week hypobaric hypoxia. (A–C) Statistical results for the mRNA expression of Col1α1, Col3α1, and endothelin-1 (ET-1) based on the real-time PCR analysis. (D) Evaluation of the ET-1 protein production in lung tissues based on ELISA. All data are expressed as mean ± SD (n = 12). NC, normal control group; HAH, high-altitude hypoxia group; and HAHO, high-altitude hypoxia with oxygen enrichment group. ^***p < 0.001 vs. the NC group, ^##p < 0.01 vs. the HAH group, and ^###p < 0.001 vs. the HAH group.