Table 6.

Histopathology scores following i.t. instillation of PBS, MIN-U-SIL and nine FSDs.¹

Dust Dose	Treatment
	PBS	MIN-U-SIL	1	2	3	4	5	6	7	8	9
Histiocytic and neutrophilic inflammation in alveoli
Low	0 (6)	0 (2)	0 (4)	0 (4)	0 (3)	0 (3)	0 (3)	0 (3)	0 (4)	0 (4)	0 (4)
		4 (2)				4 (1)
High	-	4 (1)*	0 (4)	0 (4)	0 (3)	0 (4)	0 (3)	0 (2)	0 (3)	0 (3)	0 (4)
		5 (1)					4 (1)	4 (1)
		6 (1)
Alveolar histiocytosis
Low	0 (3)	0 (3)	0 (1)	2 (1)	0 (2)	0 (1)	3 (1)	0 (3)	0 (3)	0 (1)	0 (1)
	2 (1)	2 (1)	4 (1)	4 (2)	4 (1)	2 (1)	4 (2)		4 (1)	4 (3)	3 (1)
	4 (2)		5 (2)	5 (1)		3 (1)					4 (1)
						5 (1)					5 (1)
High	-	0 (3)	0 (2)	0 (1)	0 (1)	0 (1)	0 (2)	0 (2)	0 (2)	0 (2)	2 (1)
			2 (1)	2 (1)	2 (1)	4 (2)	3 (1)	3 (1)	2 (1)	5 (1)	3 (2)
			4 (1)	3 (1)	3 (1)	5 (1)	4 (1)				6 (1)
				5 (1)
Alveolar epithelial cell hypertrophy and hyperplasia
Low	0 (6)	0 (2)	0 (4)	0 (4)	0 (3)	0 (3)	0 (3)	0 (3)	0 (4)	0 (3)	0 (4)
		2 (2)				3 (1)				2 (1)
High	-	0 (1)	0 (4)	0 (4)	0 (3)	0 (4)	0 (3)	0 (3)	0 (3)	0 (3)	0 (4)
		4 (1)
		5 (1)
Fibrosis diagnosed by trichrome
Low	0 (6)	0 (3)	0 (3)	0 (3)	0 (3)	0 (3)	0 (2)	0 (3)	0 (4)	0 (4)	0 (3)
		4 (1)	4 (1)	4 (1)		2 (1)	3 (1)				4 (1)
High	-	4 (2)*	0 (4)	0 (4)	0 (1)*	0 (1)*	0 (3)	0 (3)	0 (3)	0 (4)	0 (2)
		5 (1)			3 (3)	4 (3)	5 (1)				2 (1)
											5 (1)

¹Values are the pathology scores (severity + distribution). n numbers in parentheses.

^*Significantly different from PBS control.