Figure 3. Associations of Inflammatory and Metabolic Biomarkers per SD Increment With Incident Coronary Heart Disease (CHD) by Age at CHD Onset.

Hazard ratios (95% CI) were obtained from stratified Cox proportional hazards regression models (stratified by age groups and blood draw time categories) adjusted for model 1 covariates (baseline race/ethnicity, educational level categories, menopause, postmenopausal hormone use, randomized treatment assignment, and interactions between the risk factor of interest and age groups). Hazard ratios were based on the presence vs absence of risk factors. BCAAs indicates branched chain amino acids; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; GlycA, glycan biomarker of N-acetyl side chains of several acute-phase proteins; ICAM-1, intercellular adhesion molecule 1; and LPIR, lipoprotein insulin resistance.