Table 1.
Consensus on pharmacological strategy for Manic episodes
| Manic episode in bipolar I | Hypomanic episode in bipolar II | Manic episode in elderly | |
|---|---|---|---|
| Li + AAP | 1st | 1st | 2nd |
| Li only | 1st | 1st | 2nd |
| VAP + AAP | 1st | 2nd | 2nd |
| VAP only | 2nd | 2nd | 2nd |
| LTG + AAP | 2nd | No consensus | No consensus |
| LTG only | 3rd | 3rd | 3rd |
| CBZ only | No consensus | No consensus | 3rd |
| OLZ only | 2nd | 2nd | 2nd |
| ARP only | 2nd | 2nd | 2nd |
| QTP only | No consensus | 2nd | 2nd |
| RIS only | No consensus | No consensus | 2nd |
| ASP only | 2nd | 2nd | 3rd |
| Li + VAP | 2nd | 2nd | No consensus |
| Li + LTG | 2nd | No consensus | 2nd |
| VAP + LTG | 3rd | 3rd | 3rd |
| Li + TAP | No consensus | n.a. | n.a. |
| VAP + TAP | No consensus | n.a. | n.a. |
| LTG + TAP | 3rd | n.a. | n.a. |
| TAP only | 3rd | n.a. | n.a. |
| Li + AD | n.a. | 3rd | 3rd |
| VAP + AD | n.a. | 3rd | 3rd |
| LTG + AD | n.a. | 3rd | 3rd |
| AD only | n.a. | 3rd | 3rd |
| MS + TH | 3rd | 3rd | 3rd |
Abbreviations: AD, antidepressant; AAP, atypical antipsychotic; ARP, aripiprazole; ASP, asenapine; CBZ, carbamazepine; CI, confidence interval; Li, lithium; LTG, lamotrigine; MS, mood stabilizer; n.a. = not available; OLZ, olanzapine; QTP, quetiapine; RIS, risperidone; SD, standard deviation; TAP, typical antipsychotic; TH, thyroid hormone; VAP, valproic acid.