. 2021 Jan 21;11:12. doi: 10.1186/s13613-021-00807-7

Table 1.

Demographic summary of male and female cohorts

	Males	Females	P-value
Demographic statistics
# Patients	91 (63%)	54 (37%)
Age	67 [57, 77]	67 [58, 74]	0.63^a
Mortality	18%	19%	1.0^b
APACHE II score	20 [16 27]	19.5 [17, 26]	0.98^a
First day SOFA score	6 [4 8]	5.5 [4, 8]	0.46^a
ICU length of stay (h)	108 [67.2, 188.4]	127.2 [64.8, 213.6]	0.91^a
SPRINT duration (h)	83 [45.5, 157.3]	86.5 [39, 167]	0.81^a
T2DM (%)	13 (14%)	11 (20%)	0.4^b
Per-patient GC statistics
Median BG (mmol/L)	5.7 [5.2, 6.1]	6.0 [5.3, 6.4]	0.06^a
Median % BG 4.4–8.0 mmol/L	83 [72, 90]	82 [67, 89]	0.3^a
Median % BG < 4.0 mmol/L	1.4 [0, 5.5]	1.4 [0, 6.9]	0.42^a
Median %BG < 2.2 mmol/L	0 [0, 0]	0 [0, 0]	1.0^a
BG measurements/day	15.8 [14.4, 17.5]	15.7 [14.5, 18.2]	0.47^a
Median insulin (U/h)	3 [2, 3]	3 [2, 3]	0.26^a
Median feed excl. hours not fed (g/h)	3.5 [2.1, 5.5]	2.8 [1.8, 3.9]	< 0.01^a
Median feed excl. hours not fed (%GF)	51 [30, 80]	51 [30, 75]	0.61^a
GF (g/h)	6.5 [6.5, 7.4]	5.2 [5.2, 5.7]	< 0.01^a
Cohort statistics
Cohort BG (mmol/L)	5.6 [4.9, 6.6]	5.9 [5.0, 6.9]	< 0.01^ac
% BG 4.4–8.0 mmol/L	80.6	76.9	< 0.01^b
% BG < 4.0 mmol/L	3.2	3.8	0.11^b
%BG < 2.2 mmol/L	0	0	1.0^b
Insulin (U/h)	3 [1 4]	3 [2 4]	< 0.01^a
Hours not fed	1914 (35%)	861 (27%)	< 0.01^a
Feed excl. hours not fed (g/h)	3.8 [2.0, 5.8]	2.4 [1.7 3.9]	< 0.01^a
Feed excl. hours not fed (%GF)	55 [29 83]	47 [29 75]	< 0.01^a

P-values are not adjusted for multiple comparisons. Median [IQR] is given where appropriate. T2DM = pre-diagnosed type 2 diabetes mellitus, GF = goal feed, and BG = blood glucose. BG is hourly resampled to allow fair comparison.

Statistical difference is shown using (^a) the Wilcoxon rank-sum test or (^b) Fisher exact test where appropriate. (^c) indicates clinical equivalence regardless of statistical significance, as further explained in the methods