Table 1.

Metabolic effects of triple therapy and conventional therapy

	Triple therapy		P	Conventional therapy		P	ANOVA
	Baseline	3-years		Baseline	3-years
FPG (mg/dL)	191 ± 7	128 ± 6	<0.0001	183 ± 7	134 ± 7	<0.0001	NS
2-h PG (mg/dL)	320 ± 11	156 ± 10	<0.0001	330 ± 9	265 ± 8	<0.0001	<0.0001
HbA1c (%)	9.0% ± 0.2	6.4% ± 0.1	<0.0001	8.8% ± 0.2	6.9% ± 0.1	<0.0001	<0.0001
∆G0–120 (mg/dL/h)	227 ± 5	80 ± 9	<0.0001	216 ± 6	195 ± 8	0.006	<0.0001
∆I0–120 (µU/mL/h)	55 ± 8	64 ± 11	NS	58 ± 6	54 ± 5	NS	NS
∆C-pep0–120 (ng/mL/h)	6.5 ± 0.6	9.5 ± 0.9	0.004	7.0 ± 0.7	7.9 ± 0.7	NS	NS
(∆C-pep/∆G)0–120	0.029 ± 0.003	0.64 ± 0.15	0.0002	0.035 ± 0.004	0.047 ± 0.050	0.02	0.0001
Matsuda Index	2.9 ± 0.3	9.3 ± 1.5	0.0006	4.1 ± 0.9	3.4 ± 0.6	NS	0.0002
(∆C-pep/∆G)0–120 × Matsuda Index	0.079 ± 0.015	2.7 ± 0.5	<0.0001	0.090 ± 0.012	0.137 ± 0.018	0.01	<0.0001

∆I_0–120, change in insulin concentration. Data are mean ± SEM.