Figure 2.

Adiposity and dietary factors modulate the association between gut microbiome and type 2 diabetes. A: Association of baseline adiposity and dietary factors with the microbiome risk score (MRS). Linear regression was used to estimate the difference in MRS per quartile (for continuous dietary factors), per unit (for adiposity factors), or per category (for ordinary factors) change in the baseline tested factors, with adjustment for demographic factors and type 2 diabetes medication use and mutual adjustment for the other tested adiposity, dietary, and lifestyle factors. We only present those adipose, dietary, or lifestyle factors showing significant association with the MRS in the figure. B: Association between MRS and trunk fat–to–limb fat mass ratio in the discovery cohort and external validation cohort 1. Linear regression was used to estimate the difference in trunk fat–to–limb fat mass ratio per unit change in the MRS, with adjustment for demographic, dietary, and lifestyle factors. C: Interaction between MRS and trunk fat–to–limb fat mass ratio for type 2 diabetes risk. Poisson regression was used to estimate the interaction of MRS and trunk fat–to–limb fat mass ratio for type 2 diabetes risk, with adjustment for demographic, dietary, and lifestyle factors. RR (95% CI) of type 2 diabetes by MRS stratified by trunk fat–to–limb fat mass ratio tertile (T) or RR (95% CI) of type 2 diabetes by trunk fat–to–limb fat mass ratio stratified by MRS tertile is presented.