Table 2.

List of components included in the MRS construction

Microbiome	Taxa annotation
f__lactobacillaceae	p__Firmicutes; c__Bacilli; o__Lactobacillales; f__lactobacillaceae
c__alphaproteobacteria	p__Proteobacteria; c__alphaproteobacteria
f__mogibacteriaceae	p__Firmicutes; c__Clostridia; o__Clostridiales; f__mogibacteriaceae
g__clostridiaceae spp	p__Firmicutes; c__Clostridia; o__Clostridiales; f__Clostridiaceae; g__
c__deltaproteobacteria	p__Proteobacteria; c__deltaproteobacteria
g__butyrivibrio	p__Firmicutes; c__Clostridia; o__Clostridiales; f__Lachnospiraceae; g__butyrivibrio
o__lactobacillales	p__Firmicutes; c__Bacilli; o__lactobacillales
f__comamonadaceae	p__Proteobacteria; c__Betaproteobacteria; o__Burkholderiales; f__comamonadaceae
g__roseburia	p__Firmicutes; c__Clostridia; o__Clostridiales; f__Lachnospiraceae; g__roseburia
g__megamonas	p__Firmicutes; c__Clostridia; o__Clostridiales; f__Veillonellaceae; g__megamonas
g__mogibacteriaceae spp	p__Firmicutes; c__Clostridia; o__Clostridiales; f__mogibacteriaceae; g__
g__dorea	p__Firmicutes; c__Clostridia; o__Clostridiales; f__Lachnospiraceae; g__dorea
s__dispar	p__Firmicutes; c__Clostridia; o__Clostridiales; f__Veillonellaceae; g__Veillonella; s__dispar
Observed species (an indicator of the gut microbial diversity)

The MRS is generated based on 14 microbiome features, including 13 taxa and 1 microbial alpha-diversity index (i.e., observed species).