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. Author manuscript; available in PMC: 2021 Jan 21.
Published in final edited form as: Pharm Res. 2016 Aug 19;33(12):2904–2919. doi: 10.1007/s11095-016-2012-3

Fig. 10.

Fig. 10

In vivo pharmacokinetic-pharmacodynamic relationship in brain metastases of breast cancer after 2 hours of vinorelbine circulation. Mice harbouring MDA-MB-231BR metastases were injected with 12 mg/kg vinorelbine. Brain sections were analysed for evidence of tumor cell death (TUNEL) 2 h post-injection. Two metastases representative of relatively low and high drug uptake are shown. a TUNEL staining overlaid onto DAPI nuclear staining as visualized by fluorescence. b In vivo localized relationship of drug levels and percentage tumor cell apoptosis. C Vinorelbine concentration in brain metastases as a function of level of apoptosis.