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. Author manuscript; available in PMC: 2021 Jan 21.
Published in final edited form as: Pharm Res. 2016 Aug 19;33(12):2904–2919. doi: 10.1007/s11095-016-2012-3

Fig. 6.

Fig. 6

Pharmacokinetics of 3H-vinorelbine distribution to peripheral tissues, brain and brain metastases. a-b Pharmacokinetics of 3H-vinorelbine in various organs over 8 h following i.v. administration of vinorelbine to MDA-MB-231BR tumor-bearing mice. a Data represent mean ± SD for n = 3 animals per time point. b Brain metastases are divided into 3 groups based on uptake compared to uninvolved brain: low < (brain + 3 × SD), medium ≤ 10 × brain, high ≥ 10 × brain, to show pharmacokinetics within the groups. c Vinorelbine partition coefficient in various tissues showing greatly reduced distribution into brain metastases compared to peripheral tissues and non-barrier brain. d Projected Kp based on tubulin content in different tissues. Tubulin concentrations were obtained from Table I of Wierzba, K., et al. (33), line represents least squares fit to data.