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. Author manuscript; available in PMC: 2021 Jan 21.
Published in final edited form as: Pharm Res. 2016 Aug 19;33(12):2904–2919. doi: 10.1007/s11095-016-2012-3

Fig. 7.

Fig. 7

Vinorelbine total, bound and unbound concentration in MDA-MB-231BR experimental brain metastases of breast cancer. Representative images for determination of unbound vinorelbine concentration in 20 μm coronal brain sections from mice harbouring metastases 2 h after injection of vinorelbine. a Cresyl violet staining of brain section for tumor localization. b Fluorescence image of Texas red permeability. c QAR image of in vivo total vinorelbine. d QAR image of in vitro free fraction. e Bound vinorelbine concentration. f Unbound vinorelbine concentration. Images a-c and e-f are of the same brain section, while d is from the adjacent bran section. Images d-f were obtained following the procedure illustrated in Fig. 1 using MCID software.