Fig. 9.

³H-vinorelbine distribution within a high-uptake metastasis. a Expanded QAR image of a representative high-uptake (>10 × (uninvolved brain average vinorelbine concentration)) metastasis showing localized total (left scale) and corresponding unbound (right scale) vinorelbine. b Illustration of the concentration zones observed in a relative to calculated equilibrium concentration that would be attained in brain without barrier (19.6 μM). c Areas within high uptake brain metastases (N = 7) partitioned by concentration relative to equilibrium concentration. d Localized Texas red fluorescence measurement in the same metastasis. e Correlation between fold increase in Texas red permeability and unbound vinorelbine concentration. f Calculated K_p,uu within metastasis, with select high-uptake regions shown, which could be reaching efficacious levels.