Table I.

Plasma, Blood, and Tissue Concentrations at 0.5, 2 and 8 hr After i.v Administration of 12 mg/kg Vinorelbine

Sample	Vinorelbine concentration (μM)
	0.5 hours	2 hours	8 hours
Plasma	4.2 ± 1.3	1.6 ± 0.1	0.11 ± 0.006
Blood	4.8 ± 0.9	1.9 ± 0.5	0.11 ± 0.03
Brain	0.92 ± 0.15	0.41 ± 0.02	0.17 ± 0.03
Heart	23.4 ± 7	27 ± 1.9	12 ± 5
Lung	23 ± 3.4	25.5 ± 16.2	5.6 ± 1.3
Liver	59.2 ± 15.2	59.3 ± 14.4	32.3 ± 7
Kidney	74 ± 24.5	42 ± 4.3	24.5 ± 8
Spleen	18 ± 3.2	24 ± 3.6	13.5 ± 5
Abdominal Fat	21 ± 2.6	34.6 ± 9.4	13.5 ± 9.6
Large Intestine	7.2 ± 2.9	11.8 ± 1.7	5.3 ± 2.8
Small Intestine	28.5 ± 12.2	16.7 ± 9.4	9.62 ± 4.7
Muscle	5.2 ± 2.5	5.8 ± 0.5	2.4 ± 0.5
Bone	3.3 ± 0.8	4.7 ± 0.6	2.1 ± 1.1
Brain Metastases	1.8 (0.73–6.5)	1.7 (0.26–6.9)	0.52 (0.14–5.8)
Systemic Metastases		28 (17–29)	18.7 (5–32)

Values represent mean ± SD (n = 3), except for metastases, where the median and range are presented