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. Author manuscript; available in PMC: 2021 Jan 21.
Published in final edited form as: Pharm Res. 2016 Aug 19;33(12):2904–2919. doi: 10.1007/s11095-016-2012-3

Table II.

Integrated Vinorelbine Exposure (AUC, μmol.h.Kg−1) as Calculated by Trapezoidal Method

Sample AUC (μmol.h.Kg−1) Kp
Liver 364 ± 24 39.5 ± 2.6
Kidney 286 ± 53 31.0 ± 5.7
Fat 186 ± 16 20.2 ± 1.8
Heart 155 ± 15 16.8 ± 1.7
Lung 130 ± 58 14.1 ± 6.3
Muscle   33 ± 4 3.6 ± 0.5
Bone   26 ± 5 2.9 ± 0.6
Systemic Mets 126 ± 30 13.5 ± 3.1
Non-Barrier Brain 129 ± 17 13.7 ± 1.9
High Brain Mets   31 ± 4 3.9 ± 0.4
Medium Brain Mets   10 ± 4 1.1 ± 0.04
Low Brain Mets   3.9 ± 0.5 0.42 ± 0.05
Brain   2.7 ± 0.2 0.28 ± 0.02
Blood   12 ± 1
Plasma   9.4 ± 0.4
Blood   12 ± 1
Plasma   9.4 ± 0.4

Data represents mean ± SD (n = 3)