Table 4:

The association of caregiver/patient predictors with caregiver emotional health and quality of life outcomes in models with individual GA domains

Independent variables	Anxiety (GAD-7)	Distress	Depression (PHQ-2)	SF-12 Physical Health	SF-12 Mental Health	SF-12 Total Score
	OR (95% CI)	OR (95% CI)	OR (95% CI)	Coef. (95% CI)	Coef. (95% CI)	Coef. (95% CI)
Caregiver Predictors
Age	0.96 (0.94 – 0.99)*	0.98 (0.96–1.00)*	0.96 (0.94–0.98)**	−0.13(−0.21– −0.05)*	0.23 (0.14 – 0.31)**	0.07 (−0.04–0.18)
Female (vs male)	0.92 (0.50 – 1.71)	0.44 (0.26–0.75)*	0.74 (0.38–1.46)	2.43 (0.23–4.64)^	0.30 (−1.93 – 2.52)	2.35 (−0.64–5.34)
Non-Hispanic white (vs other)	1.17 (0.51 – 2.67)	0.86 (0.42–1.75)	0.72 (0.32–1.60)	0.15 (−2.88–3.19)	−1.78 (−4.89 – 1.33)	−1.50 (−5.62–2.63)
Income > $50,000 + ‘Decline to answer’ (vs < $50,000)	0.61 (0.37 – 1.03)	-	-	2.41 (0.50–4.33)^	-	4.27 (1.65–6.89)*
Comorbidity	2.91 (1.69 – 5.04)**	-	3.46 (1.94–6.18)**	−7.86 (−9.85– −5.87)**	−3.99 (−5.99– −1.98)**	−11.56 (−14.28– −8.85)**
Patient Predictors
Cancer type (vs GI)
Lung	1.22 (0.62 – 2.39)	1.06 (0.59–1.92)	0.86 (0.42–1.74)	−1.30 (−3.85–1.26)*	0.13 (−2.50 – 2.76)	−1.02 (−4.51–2.47)
Others	0.84 (0.45 – 1.56)	0.60 (0.35–1.01)^	0.71 (0.38–1.35)	−2.47 (−4.71– −0.24)^	0.64 (−1.66 – 2.94)	−1.85 (−4.90–1.19)
Distress (≥4)	2.03 (1.22 – 3.38)*	2.95 (1.89–4.61)**	-	-	−2.62 (−4.61 – −0.64)*	−3.97 (−6.64– −1.31)*
Impaired function	-	-	-	−2.50 (−4.45– −0.56)^	-	−4.11 (−6.73– −1.48)**
Impaired nutrition	-	1.45 (0.92–2.26)	2.08 (1.15–3.77)*	-	-	-

Note: Lower scores for the distress thermometer and PHQ-2 indicate distress and depression, respectively; while higher scores on the SF-12 indicate greater quality of life.

^{^}p-value<0.05,

^*p-value<0.01;

^**p-value<0.001

Predictors with empty cells were excluded in the stepwise procedure.

Abbreviations: GAD-7, generalized anxiety disorder 7-item scale; PHQ, patient health questionnaire; SF-12, 12-item short form health survey; OR, odds ratio; Coef, coefficient; GI, gastrointestinal; GA, geriatric assessment