Fig. 7.

Schematic model of miR‐210‐SMAD4 interaction during hepatic IR injury. Hypoxia or ischemia induced the transportation of HIF1α and SMAD4 into nucleus, which triggered the transcription of miR‐210 by directly binding to its promoter region. Up‐regulated miR‐210 matured in cytoplasm, incorporated into RNA‐induced silencing complex to pair to SMAD4 3′UTR, and subsequently suppressed the expression of SMAD4. The negative feedback of SMAD4 and miR‐210 suppressed the levels of SMAD4, which further impaired SMAD4‐mediated anti‐apoptosis and induced cell death and liver damage.