Table 3.
Comparison between patients diagnosed with TA (group A) and patients diagnosed with APA (group B)
| Group A typical adenoma |
Group B atypical adenoma |
P-value | |
|---|---|---|---|
| n = 107 | n = 10 | ||
| Male n (%) | 30 (28.0) | 5 (50.0) | 0.105 |
| Age (year) | 60 ± 13 | 62 ± 13 | 0.661 |
| BMI (kg/m2) | 25.4 ± 4.0 | 26.4 ± 3.6 | 0.258 |
| Symptomatic hypercalcemia | 13 (12.1) | 6 (60.0) | 0.001 |
| Nephrolithiasis | 34 (31.8) | 2 (20.0) | 0.722 |
| Peptic ulcers | 2 (1.9) | 1 (10.0) | 0.237 |
| Pancreatitis | 3 (2.8) | 2 1.9) | 0.304 |
| Cardiovascular disease | 16 (15.0) | 2 (20.0) | 0.651 |
| Hypertension | 53 (49.5) | 2 (20.0) | 0.101 |
| Osteoporosis | 24 (22.4) | 3 (30.0) | 0.695 |
| Fragility fracture | 1 (0.9) | 2 (20.0) | 0.019 |
| Neuropsychiatric/neurocognitive symptoms | 6 (5.6) | 1 (10.0) | 0.474 |
| Neuromuscular symptoms | 5 (4.7) | 1 10.0) | 0.422 |
| CrCl < 60 ml/min | 10 (9.3) | 1 (10.0) | 1.000 |
| Others symptoms | 14 (13.1) | 2 (20.0) | 0.625 |
| Serum creatinine (mg/dL) | 1.2 ± 0.7 | 1.1 ± 0.7 | 0.750 |
| eGFR (mL/min) | 89.2 ± 38.7 | 89.9 ± 33.3 | 0.884 |
| Preoperative serum calcium (mg/dL) | 11.7 ± 2.1 | 13.6 ± 1.5 | 0.001 |
| 25-OH vitamin D (ng/mL) | 53.2 ± 15.8 | 56.8 ± 13.4 | 0.372 |
| 24-h urinary calcium | 269.9 ± 102.8 | 376.8 ± 160.7 | 0.036 |
| Preoperatve iPTH (pg/ml) | 390.1 ± 473.6 | 1198.7 ± 1168.7 | 0.002 |
| Intraoperative iPTH (pg/ml) | 56.6 ± 68.9 | 93.1 ± 88.9 | 0.108 |
| Postoperative iPTH (pg/ml) | 24.8 ± 16.8 | 31.4 ± 22.2 | 0.099 |
| 6 mounths iPTH (pg/ml) | 23.0 ± 10.0 | 22.3 ± 6.4 | 0.696 |
| I Postoperative day serum calcium (mg/dL) | 9.1 ± 0.6 | 9.2 ± 0.6 | 0.488 |
| II Postoperative day serum calcium (mg/dL) | 9.1 ± 0.6 | 8.9 ± 0.6 | 0.111 |
| III Postoperative day serum calcium (mg/dL) | 8.9 ± 0.4 | 8.8 ± 0.6 | 0.747 |
| Follow-up time (mounths) | 60 ± 2 | 61 ± 4 | 0.551 |
| Temporary hypoparathyroidism | 6 (5.6) | 1 (10.0) | 0.474 |
| Permanent hypoparathyroidism | 0 (0.0) | 0 (0.0) | – |
| Persistent hyperparathyroidism | 0 (0.0) | 0 (0.0) | – |
Data are shown as mean ± standard deviation or number (%)
Abbreviations: TA typical adenoma, APA atypical parathyroid adenoma, BMI body mass index, CrCl creatinine clearance, eGFR estimated glomerular filtration rate, 25-OH vitamin D 25-hydroxyvitamin D3, iPTH intact-parathyroid hormone, PTX 6 months iPTH iPTH measurement 6 months later the surgery intervention