Fig. 1.

Detection of methylated DNA by clinical phenotype. A specimen was deemed positive (Pos) if at least one PCR replicate was positive for DNA methylation in at least one of the 3 genes. Black closed circles, calculated mean detection rates (%); horizontal bars, 95% CI; severity of dysplasia was available for 584 of 616 adenomas, HGD high grade dysplasia, LGD low grade dysplasia; non-neoplastic pathologies included benign polyps (hyperplastic, unspecified, inflammatory, other polyps), inflammatory bowel disease, diverticular disease, angiodysplasia, hemorrhoids; Odds ratios (95% CI) are relative to cases without neoplasia, **p < 0.0001; *p < 0.05. Two of the 184 CRC cases were unstaged [2/2, 100% (15.8–100)] and were omitted from the figure