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. 2021 Jan 21;13:14. doi: 10.1186/s13148-020-00999-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Positivity by progression of cellular atypia (dysplasia in adenomas) and degree of invasion (T stage in cancer), in cases without disseminated disease. LGD low grade dysplasia, HGD high grade dysplasia. Y axis: average detection rates, % (sensitivity). Closed black circles—at least one PCR replicate positive for methylation in any of the three genes; blue, red and black symbols—detection rates of the individual methylation markers, IRF4, IKZF1 and BCAT1, respectively. Additional file 1: Table S1 provides details for count of positives, % detected and 95% CI. *Only 53 of the 57 Stage II cases had full TNM information