Fig. 3.

Concordance between positive methylated BCAT1, IKZF1 and IRF4 results in plasma. The number of positive specimens is shown for each phenotype, together with the numbers returning a positive for each BCAT1, IKZF1 and IRF4 combination.¹There were two unstaged cancer cases, both positive for methylation, which are not included in the CRC Stage Venn diagrams. Severity of dysplasia was available for 584 of 616 adenomas, HGD high grade dysplasia, LGD low grade dysplasia; non-neoplastic pathologies included benign polyps (hyperplastic, unspecified, inflammatory, other polyps), inflammatory bowel disease, diverticular disease, angiodysplasia, hemorrhoids