Table 3.
Test accuracy for detection of colorectal cancer based on all possible gene combinations
| Gene combination | Counts | Sensitivity % (95% CI) | Specificity % (95% CI) | AUC (95% CI) | LRP (95% CI) | |
|---|---|---|---|---|---|---|
| TP | TN | |||||
| BCAT1 only | 87 | 776 |
47.3 (40.2–54.5) |
94.6 (92.9–96.0) |
0.710 (0.662–0.757) |
8.8 (6.4–12.2) |
| IRF4 only | 92 | 802 |
50.0 (42.8–57.2) |
97.8 (96.6–98.6) |
0.739 (0.691–0.787) |
22.8 (14.1–36.8) |
| IKZF1 only | 109 | 785 |
59.2 (52.0–66.1) |
95.7 (94.1–96.9) |
0.775 (0.730–0.820) |
13.9 (9.8–19.6) |
| BCAT1 and-or IRF4 | 110 | 761 |
59.8 (52.6–66.6) |
92.8 (90.8–94.4) |
0.763 (0.718–0.808) |
8.31 (6.3–10.9) |
| IKZF1 and-or IRF4 | 128 | 773 |
69.6 (62.6–75.8) |
94.3 (92.5–95.7) |
0.819 (0.778–0.860) |
12.1 (9.1–16.3) |
| BCAT1 and-or IKZF1 | 129 | 750 |
70.1 (63.1–76.3) |
91.5 (89.4–93.2) |
0.808 (0.767–0.849) |
8.21 (6.4–10.5) |
| Any of the 3 genes | 136 | 739 |
73.9 (67.1–79.7) |
90.1 (87.9–92.0) |
0.820 (0.781–0.859) |
7.48 (6.0–9.4) |
The true- and false-positive rates in cases with cancer (n = 184) and cases without neoplasia (n = 820) were used for sensitivity (for cancer) and specificity (for neoplasia) estimates
TP Counts of true positives, TN Counts of true negatives, AUC area under the curve of ROC plots shown in Fig. 5, LRP positive likelihood ratio