Table 3.

Main GO pathways significantly relating to major hubs

Term	Pathway	Count	Pop hits	P Value
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	32	981	9.79E−16
GO:0043066	Negative regulation of apoptotic process	25	455	4.13E−17
GO:0045893	Positive regulation of transcription, DNA-templated	24	515	8.12E−15
GO:0007165	Signal transduction	21	1161	6.17E−06
GO:0010628	Positive regulation of gene expression	18	262	9.90E−14
GO:0042493	Response to drug	17	304	1.37E−11
GO:0006915	Apoptotic process	17	567	1.08E−07
GO:0006954	Inflammatory response	16	379	3.26E−09
GO:0000122	Negative regulation of transcription from RNA polymerase II promoter	16	720	1.19E−05
GO:0008285	Negative regulation of cell proliferation	15	396	4.72E−08
GO:0032355	Response to estradiol	14	91	3.49E−15
GO:0008284	Positive regulation of cell proliferation	14	466	2.15E−06
GO:0071456	Cellular response to hypoxia	13	96	2.22E−13
GO:0001525	Angiogenesis	13	223	4.64E−09
GO:0006468	Protein phosphorylation	13	456	9.88E−06
GO:0045892	Negative regulation of transcription, DNA-templated	13	499	2.42E−05
GO:0001666	Response to hypoxia	12	172	3.51E−09
GO:0006974	Cellular response to DNA damage stimulus	12	208	2.54E−08
GO:0000165	MAPK cascade	12	262	2.66E−07
GO:0008283	Cell proliferation	12	366	6.90E−06