Table 1.
Up-regulated genes of interest (GOIs) after exposure of HSAEpC to various dilutions of cannabis oil extract for 24 h
| Symbol | Description | 1:400 Dil. | 1:800 Dil. | 1:1600 Dil. | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fold Change | 95% CI | P-value | Fold Change | 95% CI | P-value | Fold Change | 95% CI | P-value | ||
| BCL6 | B-cell leukemia/lymphoma 6 | 2.408 | (1.94, 2.88) | 0.00006 | ||||||
| CCL22 | Chemokine (C-C motif) ligand 22 | 5.309 | (2.69, 7.93) | 0.00045 | 5.249 | (2.83, 7.67) | 0.00022 | |||
| CCL24 | Chemokine (C-C motif) ligand 24 | 59.800 | (42.54, 77.06) | < 0.00001 | ||||||
| CCL26 | Chemokine (C-C motif) ligand 26 | 5.396 | (3.50, 7.29) | < 0.00001 | ||||||
| CSF2 | Colony stimulating factor 2 (granulocyte-macrophage) | 148.914 | (118.08, 179.74) | < 0.00001 | 47.615 | (39.28, 55.95) | < 0.00001 | 4.018 | (3.33, 4.70) | < 0.00001 |
| IL4 | Interleukin 4 | 8.696 | (6.26, 11.13) | 0.00001 | 12.324 | (9.57, 15.08) | < 0.00001 | 3.679 | (2.41, 4.95) | 0.00038 |
| IL12A | Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 6.789 | (2.15, 11.43) | 0.00048 | ||||||
| IL12B | Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5.196 | (0.00001, 10.54) | 0.03230 | ||||||
| IL13RA2 | Interleukin 13 receptor, alpha 2 | 19.244 | (16.80, 21.69) | < 0.00001 | 23.779 | (21.19, 26.37) | < 0.00001 | 5.049 | (4.19, 5.91) | < 0.00001 |
| IL17A | Interleukin 17A | 33.457 | (21.68, 45.24) | 0.00004 | 35.543 | (25.63, 45.46) | < 0.00001 | 7.563 | (5.64, 9.49) | < 0.00001 |
| IL1RL1 | Interleukin 1 receptor-like 1 | 180.497 | (122.94, 238.06) | < 0.00001 | 161.270 | (105.45, 217.09) | < 0.00001 | 7.296 | (4.95, 9.64) | < 0.00001 |
| PPARG | Peroxisome proliferator-activated receptor gamma | 5.415 | (4.81, 6.02) | < 0.00001 | 7.367 | (6.40, 8.34) | < 0.00001 | 3.004 | (2.63, 3.38) | < 0.00001 |
| PRG2 | Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 2.600 | (2.04, 3.16) | 0.00004 | ||||||
| PTGDR2 | Prostaglandin D2 receptor 2 | 3.725 | (1.55, 5.90) | 0.00374 | ||||||
| TBX21 | T-box 21 | 28.785 | (23.31, 34.26) | < 0.00001 | ||||||
| TSLP | Thymic stromal lymphopoietin | 11.999 | (9.61, 14.39) | < 0.00001 | 2.602 | (2.03, 3.18) | 0.00002 | |||