Table 2.
Down-regulated GOIs after exposure of HSAEpC to various dilutions of cannabis oil extract for 24 h
| Symbol | Description | 1:400 Dil. | 1:800 Dil. | 1:1600 Dil. | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fold Change | 95% CI | P-value | Fold Change | 95% CI | P-value | Fold Change | 95% CI | P-value | ||
| ADRB2 | Adrenergic receptor, beta 2 | 0.462 | (0.40, 0.53) | 0.00001 | ||||||
| AREG | Amphiregulin | 0.476 | (0.41, 0.54) | < 0.00001 | ||||||
| CCL5 | Chemokine (C-C motif) ligand 5 | 0.226 | (0.10, 0.36) | 0.00119 | ||||||
| CLCA1 | Chloride channel accessory 1 | 0.129 | (0.03, 0.23) | 0.02891 | 0.162 | (0.06, 0.26) | 0.03048 | |||
| CMA1 | Chymase 1, mast cell | 0.068 | (0.04, 0.10) | 0.00037 | 0.353 | (0.20, 0.50) | 0.00421 | |||
| EPX | Eosinophil peroxidase | 0.037 | (0.03, 0.04) | < 0.00001 | 0.213 | (0.11, 0.31) | < 0.00001 | |||
| FOXP3 | Forkhead box P3 | 0.257 | (0.12, 0.40) | 0.00038 | ||||||
| IL3RA | Interleukin 3 receptor, alpha (low affinity) | 0.344 | (0.16, 0.52) | 0.00364 | ||||||
| IL4R | Interleukin 4 receptor | 0.261 | (0.24, 0.28) | < 0.00001 | ||||||
| IL5 | Interleukin 5 (colony-stimulating factor, eosinophil) | 0.319 | (0.06, 0.58) | 0.01014 | ||||||
| IL13RA1 | Interleukin 13 receptor, alpha 1 | 0.343 | (0.29, 0.40) | < 0.00001 | ||||||
| IL33 | Interleukin 33 | 0.185 | (0.16, 0.21) | < 0.00001 | ||||||
| LTB4R | Leukotriene B4 receptor | 0.194 | (0.16, 0.23) | < 0.00001 | 0.451 | (0.39, 0.52) | 0.00001 | |||
| MAF | V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) | 0.237 | (0.20, 0.28) | < 0.00001 | 0.330 | (0.29, 0.37) | 0.00001 | |||
| MMP9 | Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) | 0.274 | (0.22, 0.33) | 0.00001 | ||||||
| PMCH | Pro-melanin-concentrating hormone | 0.271 | (0.17, 0.37) | 0.00188 | 0.087 | (0.03, 0.14) | 0.00047 | |||
| POSTN | Periostin, osteoblast specific factor | 0.176 | (0.16, 0.19) | < 0.00001 | ||||||
| RORC | RAR-related orphan receptor C | 0.180 | (0.00001, 0.36) | 0.02731 | ||||||
| SATB1 | SATB homeobox 1 | 0.481 | (0.31, 0.65) | 0.00148 | ||||||
| STAT5A | Signal transducer and activator of transcription 5A | 0.328 | (0.27, 0.38) | 0.00001 | ||||||
| TNFSF4 | Tumor necrosis factor (ligand) superfamily, member 4 | 0.197 | (0.08, 0.31) | < 0.00001 | ||||||