Table 4.

Patents on medical cannabis upstream technologies (in planta genetic engineering)

Title	Short description	Patent doc. number
Plants and methods for increasing and decreasing synthesis of cannabinoids (US20200181631A1 - Plants and methods for increasing and decreasing synthesis of cannabinoids - Google Patents n.d.)	CRISPR/Cas9 system gene editing system to alter the expression of cannabinoids in plants	US20200181631A
Modulation of cannabinoid profile in cannabis (WO2020035869A1 - Modulation of cannabinoid profile in cannabis - Google Patents n.d.)	Gene editing technology to modify metabolite pathways in the cannabis plant or cells	WO2020035869A1
Systems and methods for enhancing trichome formation and density in cannabis (US20190352662A1 - Systems and methods for enhancing trichome formation and density in cannabis - Google Patents n.d.)	Insertion of heterologous genetic material to create a plant with upregulated trichome formation	US20190352662A1
Trichome specific promoters for the manipulation of cannabinoids and other compounds in glandular trichomes (US20190225975A1 - Trichome specific promoters for the manipulation of cannabinoids and other compounds in grandular trichomes - Google Patents n.d.)	Glandular trichomes of the cannabis plants are genetically engineered to produce cannabinoids in Cannabis sativa, and also in Nicotiana. tabacum	US20190225975A1