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. Author manuscript; available in PMC: 2021 Jan 21.
Published in final edited form as: J Thromb Haemost. 2020 Oct 25;19(1):7–19. doi: 10.1111/jth.15097

Figure 5. Myosin effects on in vivo hemostasis and thrombosis in murine injury models.

Figure 5.

(A) Tail bleeding in acquired hemophilia A mice. wt-C57BL/6J mice were treated with anti-FVIII Mab to induce a bleeding tendency due to acquired hemophilia A. When SkM or CM (5.4 mg/kg) or vehicle was given i.v. 15 min before tail clipping and then tail bleeding after cutting was quantified, SkM and CM each very significantly reduced blood loss [13, 16]. (B) Murine myocardial ischemia reperfusion injury. When wt-C57BL/6J mice (n=6/group) subjected to myocardial ischemia reperfusion injury were given CM (5.4 mg/kg) or vehicle via intraarterial infusion at 15 min after initiation of reperfusion, serum cardiac troponin I levels measured at 3 hours after injury initiation were increased [16]. 100% was defined as the median of control vehicle group values. Bars show medians and p values were calculated by Mann-Whitney test.