Table 4.
Summary of clinically relevant cut-offs for several cardiac MRI metrics which have prognostic significance.
| First Author | Cardiac MRI metric | Thresholds for prognosis | Quantification and segmentation methods |
|---|---|---|---|
| Murtagh G. 2016 |
LGE | LGE volume 5.7% | Signal intensity >5 SD above the mean signal intensity of remote myocardium |
| Kato S. 2015 |
LGE | LGE volume 6% | Signal intensity >2 SD above the mean signal intensity of a remote myocardium |
| Pöyhönen P. 2014 |
LGE | LGE volume ≥ 17% | Visual scoring on AHA 17-segment model of the LV |
| Kanagala P. 2019 |
iECV\ECV | iECV >16.8 ml/m2 ECV >30.7 |
iECV = ECV (%) × indexed LVEDV |
| Schelbert E.B. 2017 |
ECV | ECV >29% | ECV = λ × (1 − haematocrit), where λ = (ΔR1myocardium)/(ΔR1bloodpool) |
| Duca F. 2016 |
ECV | ECV >28.9% | ECV = λ × (1 − haematocrit), where λ = (ΔR1myocardium)/(ΔR1bloodpool) |
| Mascherbauer J. 2013 |
Post-contrast T1 | T1 time < 388.3 ms | Measured in undefined myocardium |
| Kanagala P. 2018 |
Tissue characterisation + Stress CMR |
Perfusion defect [24] | Full clinical assessment leading to new diagnosis |
| Aschauer S. 2016 |
RVSD | RV EF <45% | Standard volumetric contours |
Abbreviations: AHA, american heart association; CI, confidence interval; ECV, extracellular volume; FU, follow-up (in months); HR, hazard ratio; iECV, total extracellular volume of the myocardium indexed to body surface area; LGE, late gadolinium enhancement; LV, left ventricle; LVEDV, left ventricular end-diastolic volume; MRI, magnetic resonance imaging; RVEF, right ventricle ejection fraction; RVSD, right ventricular systolic dysfunction; SD, standard deviation.