Table 1:
HC-Aβ (n=15) | LBD Total (n=20) | LBD-Aβ (n=9) | LBD+Aβ (n=11) | AD+Aβ (n=12) | |
---|---|---|---|---|---|
Clinical Phenotype, count | NA | DLB: 15 PD-MCI: 4 PDD: 1 |
DLB: 6 PD-MCI: 3 |
DLB: 9 PD-MCI: 1 PDD: 1 |
Dementia: 7 MCI: 5 |
Sex*, count | Male: 8 Female: 7 |
Male: 17 Female: 3 |
Male: 7 Female: 2 |
Male: 10 Female: 1 |
Male: 3 Female: 9 |
Race, count | White: 13 Black: 2 |
White: 20 | White: 9 | White:11 | White:12 |
Age of Onset | NA | 62.8 (6.2) | 61.7 (6.4) | 63.6 (6.3) | 62.0 (9.2) |
Disease duration at scana | NA | 5.4 (3.5) | 6.2 (3.0) | 3.9 (2.9) | 9 (4.9) |
Age at scan | 72.7 (6.0) | 67.7 (5.6) | 67.9 (6.6) | 67.5 (4.9) | 71.4 (5.9) |
Education# | 14.5 (3.1) | 15.7 (2.5) | 17.3 (1.7) | 14.3 (2.3) | 15.9 (3.0) |
MMSEb† | 29.3 (0.9) | 27.0 (2.7) | 28.4 (1.1) | 25.8 (3.1) | 24.3 (5.6) |
CDR-Sum of Boxes‡ | 0 (0) | N=15 4.87 (2.8) |
N=7 3.64 (1.5) |
N=8 5.94 (3.4) |
4.25 (3.1) |
Data shown is mean (SD) from the entirety of the group unless otherwise specified.
NA: not applicable. There were no significant differences in age at scan, MMSE, or CDR-Sum of boxes between the AD+Aβ group and the LBD total cohort.
Fisher exact Chi2 p=0.005.
ANOVA F(3,43)=3.0, p=0.04.
ANOVA F(3,43)=6.1, p=0.002.
ANOVA F(3,37)=10.7, p<0.001
time from MCI onset used for AD+Aβ.
MMSE closest to PET scan was assessed. If a MoCA was performed closer to PET scan, MoCA score was converted to equivalent MMSE score