. Author manuscript; available in PMC: 2021 Jan 21.

Published in final edited form as: Surg Oncol Clin N Am. 2019 Oct 29;29(1):63–72. doi: 10.1016/j.soc.2019.08.005

Table 1.

Examples of the range of precision medicine trials in pediatric oncology

Study Design	Clinical Trial	Sponsor	NCT
*Relapsed or Refractory Cancers*
Basket studies across multiple histologies	Pediatric MATCH	NCI-COG
Basket studies across multiple histologies	AcSé-ESMART	Gustave Roussey	NCT02813135

Histology-specific umbrella studies	NEPENTHE (Neuroblastoma)	CHOP	NCT02780128
	Ruxolitinib or Dasatinib + chemotherapy in Ph-like ALL	MD Anderson	NCT02420717
	RELPALL (ALL)	St. Jude	NCT03515200

*Newly Diagnosed Cancers*
Histology-specific umbrella studies	Dasatinib + chemotherapy for Ph-like ALL	COG	NCT02883049
	Ruxolitinib + chemotherapy for CRLF2/JAK/STAT mutations in ALL	COG	NCT02723994
	Crizotinib + chemotherapy in ALK aberrant neuroblastoma	COG	NCT03126916
	Total therapy XVII JAK/STAT mutations in ALL/lymphoma	St. Jude	NCT03117751
	Clinical/Molecular Risk-Directed Therapy in Medulloblastoma	St. Jude	NCT01878617
	BIOMEDE (DIPG)	Gustave Roussy	NCT02233049

NCT, ClinicalTrials.gov Identifier/Number; COG, Children’s Oncology Group; CHOP, Children’s Hospital of Philadelphia; ALL, acute lymphoblastic leukemia; DIPG, diffuse intrinsic pontine glioma