Table 3.
C-index and ROC analysis for the prognostic accuracy of Fib-PNI-MLR and other variables for OS, CSS, and MFS.
| Variables | c-index(95% CI) | AUC(95% CI) | Sensitivity% | Specificity% | Youden index | Positive likelihood ratio | Negative likelihood ratio |
|---|---|---|---|---|---|---|---|
| OS | |||||||
| Fib-PNI-MLR | 0.787 (0.730–0.844) |
0.791 (0.730–0.853) |
77.4% | 72.8% | 0.502 | 2.841 | 0.31 |
| NLR | 0.640 (0.573–0.707) |
0.652 (0.576–0.729) |
41.9% | 82.9% | 0.248 | 2.45 | 0.70 |
| Pathologic T stage | 0.658 (0.588–0.728) |
0.621 (0.542–0.700) |
41.9% | 81.6% | 0.235 | 2.28 | 0.71 |
| Fuhrman grade | 0.664 (0.598–0.730) |
0.703 (0.637–0.770) |
53.2% | 79.5% | 0.327 | 2.60 | 0.59 |
| pT+Fib-PNI-MLR | 0.808 (0.747–0.869) |
0.803 (0.741–0.865) |
82.5% | 71.6% | 0.541 | 2.90 | 0.24 |
| Grade+Fib-PNI-MLR | 0.823 (0.770–0.876) |
0.835 (0.781–0.888) |
74.2% | 78.4% | 0.526 | 3.43 | 0.33 |
| CSS | |||||||
| Fib-PNI-MLR | 0.810 (0.744–0.876) |
0.810 (0.740–0.880) |
82.5% | 71.6% | 0.541 | 2.90 | 0.24 |
| NLR | 0.687 (0.606–0.768) |
0.679 (0.584–0.774) |
65.0% | 69.5% | 0.345 | 2.13 | 0.50 |
| Pathologic T stage | 0.700 (0.616–0.784) |
0.660 (0.564–0.756) |
50.0% | 81.4% | 0.314 | 2.69 | 0.61 |
| Fuhrman grade | 0.700 (0.621–0.779) |
0.727 (0.647–0.807) |
60.0% | 79.0% | 0.390 | 2.86 | 0.51 |
| pT+Fib-PNI-MLR | 0.842 (0.776–0.908) |
0.835 (0.770–0.900) |
82.5% | 71.6% | 0.541 | 2.90 | 0.24 |
| Grade+Fib-PNI-MLR | 0.855 (0.800–0.910) |
0.861 (0.804–0.918) |
90.0% | 70.3% | 0.603 | 3.03 | 0.14 |
| MFS | |||||||
| Fib-PNI-MLR | 0.719 (0.660–0.778) |
0.697 (0.630–0.764) |
61.0% | 72.3% | 0.333 | 2.20 | 0.54 |
| NLR | 0.635 (0.578–0.692) |
0.653 (0.587–0.720) |
58.5% | 67.2% | 0.257 | 1.78 | 0.62 |
| BMI | 0.576 (0.537–0.611) |
0.586 (0.530–0.642) |
41.8% | 78.0% | 0.198 | 1.90 | 0.75 |
| CKD stage | 0.572 (0.526–0.618) |
0.588 (0.519–0.658) |
45.1% | 69.9% | 0.150 | 1.50 | 0.79 |
| Pathologic T stage | 0.637 (0.578–0.696) |
0.618 (0.549–0.687) |
41.5% | 82.2% | 0.237 | 2.33 | 0.71 |
| Fuhrman grade | 0.630 (0.572–0.688) |
0.674 (0.613–0.736) |
47.6% | 79.8% | 0.274 | 2.36 | 0.66 |
| pT+Fib-PNI-MLR | 0.745 (0.684–0.806) |
0.733 (0.669–0.796) |
57.3% | 81.3% | 0.386 | 3.06 | 0.53 |
| Grade+Fib-PNI-MLR | 0.759 (0.702–0.816) |
0.771 (0.714–0.828) |
78.0% | 64.0% | 0.440 | 2.29 | 0.34 |
RCC, renal cell carcinoma; CKD, chronic kidney disease; OS, overall survival; CSS, cancer-specific survival; MFS, metastatic-free survival; PNI, prognostic nutritional index; NLR, neutrophil-lymphocyte ratio.