Table 2.

Number of Symptoms and Severity Level of Symptoms for Symptomatic Subjects

Time Point	Patients		Controls		P Value for Patients vs Controls
	No. of Symptoms for Those With Symptoms	Total Severity Score	No. of Symptoms for Those With Symptoms	Total Severity Score	No. of Symptoms for Those With Symptoms	Total Severity Score
Baseline	4.15 ± 3.04 (1–11) (n = 39)	14.59 ± 15.44 (0.4–62.6)	2.02 ± 1.22 (1–6) (n = 53)	4.37 ± 5.10 (0.2–23.7)	<.001	<.001
6 mo	2.11 ± 1.29 (1–6) (n = 18)	7.38 ± 6.94 (1.7–29.1)	2.10 ± 1.31 (1–6) (n = 49)	4.41 ± 4.52 (0.2–22.1)	.98	.11
12 mo	1.78 ± 1.26 (1–6) (n = 27)	4.74 ± 4.32 (0.5–15.5)	1.84 ± 1.62 (1–8) (n = 50)	4.82 ± 5.78 (0.3–30.5)	.85	.91
Last visita	1.78 ± 1.26 (1–6) (n = 27)	4.74 ± 4.32 (0.5–15.5)	1.88 ± 1.65 (1–8) (n = 52)	4.89 ± 5.70 (0.3–30.5)	.75	.86
6 mo, ≥2 wk	1.91 ± 1.24 (1–5) (n = 11)	7.61 ± 5.97 (2.2–20.8)	1.23 ± 0.52 (1–3) (n = 22)	3.88 ± 3.14 (0.6–14.4)	.12	.09
12 mo, ≥2 wk	1.86 ± 1.30 (1–5) (n = 14)	7.98 ± 6.21 (1.2–25.3) (n = 13)b	1.96 ± 1.46 (1–6) (n = 25)	7.32 ± 7.31 (0.7–30.4)	.83	.95

Data are presented as mean ± standard deviation (range) unless otherwise indicated.

^aLast visit was at 12 months or 6 months depending on compliance.

^bFor 1 subject of the 14 with symptoms, the severity score was not available.