Table 2.
Comparison of Median and Between-Patient Variability (% CV) in AUC0–24h After Flat-Dosing and Weight-Band Dosing
| Median AUC0–24h (% CV) Day 7 | Median AUC0–24h (% CV) Day 14 | ||||||
|---|---|---|---|---|---|---|---|
| mg/kg Weight-Band Dose (mg Flat Dose) | Number of Simulated Subjects | Weight-Band Dosing | Flat-Dosing | Difference in Median (%) | Weight-Band Dosing | Flat-Dosing | Difference in Median (%) |
| 10 (600) | 8000 | 40.60 (53) | 56.85 (46) | 40.02 | 36.50 (50) | 50.77 (43) | 39.10 |
| 20 (1200) | 15 000 | 133.45 (48) | 144.36 (48) | 8.18 | 116.56 (45) | 126.72 (46) | 8.72 |
| 25 (1500) | 15 000 | 167.01 (50) | 195.12 (50) | 16.83 | 145.62 (46) | 168.84 (47) | 15.95 |
| 30 (1800) | 15 000 | 219.35 (50) | 253.59 (51) | 15.61 | 189.40 (46) | 218.71 (47) | 15.48 |
| 35 (2100) | 15 000 | 278.53 (53) | 283.39 (56) | 1.74 | 238.30 (49) | 242.94 (49) | 1.95 |
| 40 (2400) | 15 000 | 332.32 (58) | 385.68 (64) | 16.06 | 283.63 (49) | 329.15 (55) | 16.05 |
Abbreviations: AUC, area under the curve; CV, coefficient of variation.