Figure 2.

CpG sites associated with urbanization were distributed nonrandomly throughout the genome of great titsParus major. Under‐/over‐representation of urbanization‐associated sites in various regulatory and nonregulatory regions of the genome is illustrated in the liver (grey) and blood (black). Urbanization‐linked differences in DNA methylation were under‐represented in the regulatory regions of promoters, transcription start sites (TSS), gene bodies and CpG islands (CGI; blood only), but were more likely to occur within CGI shores, the regulatory regions flanking CpG islands. Differentially methylated sites were under‐represented in nonregulatory regions in liver, but over‐represented in un‐annotated regions in blood