Fig 1. Manhattan plot showing the MR relationships between gene expression changes and schizophrenia risk.

Chromosomal position is on the x-axis and p-value for the Wald ratio estimate (-log10 scaled) is on the y-axis. The prioritised genes which passed the multiple correction threshold (solid red line) and colocalization analysis (PP₄>70%) are annotated as diamonds and labelled with the gene name. FAM86B3P and FAM85B genes on chromosome 8 and AC243562.2, GOLGA2P7 and NMB genes and FURIN and FES genes on chromosome 15 are located close together (in LD with each other), challenging attribution of the causal gene at these loci.